5-Amino-1MQ 500mg Kit

5-Amino-1MQ (5-amino-1-methylquinolinium) is a synthetic small molecule that selectively inhibits Nicotinamide N-methyltransferase (NNMT). NNMT is an enzyme that methylates nicotinamide (vitamin B3) using S-adenosylmethionine (SAM) as a methyl donor. In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability.

By inhibiting NNMT, 5-Amino-1MQ may spare nicotinamide for NAD+ synthesis, thereby activating SIRT1 (Sirtuin 1) pathways associated with mitochondrial biogenesis and fat oxidation. Preclinical studies indicate that NNMT knockdown or inhibition can protect against diet-induced weight gain and improve metabolic parameters without reducing food intake.

This product contains 5-Amino-1MQ in lyophilized (freeze-dried) powder form, requiring reconstitution before use.

Product Details

5-Amino-1MQ (5-amino-1-methylquinolinium) is a synthetic small molecule that selectively inhibits Nicotinamide N-methyltransferase (NNMT). NNMT is an enzyme that methylates nicotinamide (vitamin B3) using S-adenosylmethionine (SAM) as a methyl donor. In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability.

By inhibiting NNMT, 5-Amino-1MQ may spare nicotinamide for NAD+ synthesis, thereby activating SIRT1 (Sirtuin 1) pathways associated with mitochondrial biogenesis and fat oxidation. Preclinical studies indicate that NNMT knockdown or inhibition can protect against diet-induced weight gain and improve metabolic parameters without reducing food intake.

Why Choose 5-Amino-1MQ 500mg Kit?

Complementary strategies for best outcomes.

• Pair with a balanced, protein-forward diet tailored to energy needs.
• Combine resistance training and aerobic activity—preclinical data suggest synergy with exercise.
• Prioritise sleep and stress management to support metabolic adaptation.
• Consider complementary NAD+ precursors (NMN/NR) per emerging stack protocols.
  

  Key Benefits

  Observations from preclinical and early research literature.

  • May support reductions in fat mass while preserving lean muscle in animal models.
  • Associated with elevated NAD+ levels and SIRT1 activation in preclinical studies.
  • Enhanced grip strength observed in aged mice when combined with exercise.
  • Generally well tolerated; occasional reports of mild headache, transient jitteriness, or injection-site reactions.
  • Long-term human safety data not established; this compound remains investigational.
    

    Reconstitution Instructions

    • Reconstitute using Bacteriostatic Water (BAC)

    • Example: Add 1mL of BAC to a 5mg vial for a 5mg/mL solution

    • Gently swirl (do not shake) until dissolved completely

    • Store reconstituted 5-Amino-1mQ in the refrigerator (2–8°C)

    • Use within 28 days of reconstitution

    Typical Dosing Guidelines

    • Start: 2.5 mg once daily to assess tolerance.

    • Target: 5 mg once daily or 2.5 mg twice daily (BID).

    • Frequency: Once or twice per day (subcutaneous).

    • Vial Duration: Single 10 mg vial lasts 2–4 days at research doses.

    • Timing: Morning administration preferred; BID dosing may be split AM/PM.

    Note

    This content is intended for therapeutic educational purposes only and does not constitute medical advice, diagnosis, or treatment.